Abstract The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder originally described
by Dr. Alfred Wiskott in 1937 and Dr. Robert Aldrich in 1954 as a familial disease …

Monogenic disorders have provided fundamental insights into human immunity and the
pathogenesis of allergic diseases. The pathways identified as critical in the development of …

Abstract Mutations in Wiskott–Aldrich syndrome protein (WASP) cause autoimmune
sequelae including colitis. Yet, how WASP mediates mucosal homeostasis is not fully …

Background Peanut allergy (PA) is potentially life-threatening and generally persists for life.
Recent data suggest the skin might be an important route of initial sensitization to peanut …

Immunoglobulin E–mediated food allergy is rapidly developing into a global health problem.
Publicly available therapeutic intervention strategies are currently restricted to allergen …

Defining and examining diseases with primary features of atopy and infection allow for a
better understanding of the interplay between the two in rare disease, and hopefully sheds …

Abstract Purpose of Review Food allergy likely arises from a complex interplay between
environmental triggers and genetic susceptibility. Here, we review recent studies that have …

Stimulation of naïve CD4 T cells with weak T cell receptor agonists even in the absence of T
helper-skewing cytokines can result in IL-4 production which can drive a Th2 response …