[HTML][HTML] Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
Barriers and strategies to achieve a cure for HIV
9 years since the report of a cure for HIV after CC chemokine receptor type 5 Δ32 stem cell
transplantation, no other case of HIV cure has been reported, despite much research …
transplantation, no other case of HIV cure has been reported, despite much research …
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
DJ Colby, L Trautmann, S Pinyakorn, L Leyre… - Nature medicine, 2018 - nature.com
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might
minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after …
minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after …
Gut-selective integrin-targeted therapies for inflammatory bowel disease
Integrins are cell surface receptors with bidirectional signalling capabilities that can bind to
adhesion molecules in order to mediate homing of leukocytes to peripheral tissues. Gut …
adhesion molecules in order to mediate homing of leukocytes to peripheral tissues. Gut …
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals
M Uzzan, M Tokuyama, AK Rosenstein… - Science translational …, 2018 - science.org
Gut homing CD4+ T cells expressing the integrin α4β7 are early viral targets and contribute
to HIV-1 pathogenesis, likely by seeding the gastrointestinal (GI) tract with HIV. Although …
to HIV-1 pathogenesis, likely by seeding the gastrointestinal (GI) tract with HIV. Although …
Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes
The gastrointestinal (GI) mucosa is central to HIV pathogenesis, and the integrin α4β7
promotes the homing of immune cells to this site, including those that serve as viral targets …
promotes the homing of immune cells to this site, including those that serve as viral targets …
ALT-803 transiently reduces simian immunodeficiency virus replication in the absence of antiretroviral treatment
AL Ellis-Connell, AJ Balgeman, KR Zarbock… - Journal of …, 2018 - Am Soc Microbiol
Developing biological interventions to control human immunodeficiency virus (HIV)
replication in the absence of antiretroviral therapy (ART) could contribute to the development …
replication in the absence of antiretroviral therapy (ART) could contribute to the development …
[HTML][HTML] The Role of Integrin α4β7 in HIV Pathogenesis and Treatment
J Arthos, C Cicala, F Nawaz, SN Byrareddy… - Current HIV/AIDS …, 2018 - Springer
Abstract Purpose of Review Acute HIV infection is characterized by high-level viral
replication throughout the body's lymphoid system, particularly in gut-associated lymphoid …
replication throughout the body's lymphoid system, particularly in gut-associated lymphoid …
[HTML][HTML] The latest evidence for possible HIV-1 curative strategies
HT Pham, T Mesplède - Drugs in context, 2018 - ncbi.nlm.nih.gov
Human immunodeficiency virus type 1 (HIV-1) infection remains a major health issue
worldwide. In developed countries, antiretroviral therapy has extended its reach from …
worldwide. In developed countries, antiretroviral therapy has extended its reach from …
Mathematical models of HIV latency
AL Hill - HIV-1 latency, 2018 - Springer
Viral latency is a major barrier to curing HIV infection with antiretroviral therapy, and
consequently, for eliminating the disease globally. The establishment, maintenance, and …
consequently, for eliminating the disease globally. The establishment, maintenance, and …