Research into dementia prevention is of paramount importance if the dementia epidemic is
to be halted. Observational studies have identified several potentially modifiable risk factors …

Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

This article describes the public health impact of Alzheimer's disease (AD), including
incidence and prevalence, mortality and morbidity, costs of care, and the overall impact on …

Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural
syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic …

Nutrition is an important lifestyle factor that can modify the risk of future cognitive impairment
and dementia. Some, but not conclusive, evidence (mostly from observational studies and …

During evolution, individuals whose brains and bodies functioned well in a fasted state were
successful in acquiring food, enabling their survival and reproduction. With fasting and …

The term vascular cognitive impairment (VCI) was introduced around the start of the new
millennium and refers to the contribution of vascular pathology to any severity of cognitive …

Postoperative cognitive dysfunction (POCD) is an objectively measured decline in cognition
postoperatively compared with preoperative function. POCD has been considered in the …

Introduction We examined and compared plasma phospho-tau181 (pTau181) and total
tau:(1) across the Alzheimer's disease (AD) clinical spectrum;(2) in relation to brain amyloid …

The greatest unmet therapeutic need in Parkinson's disease is the development of treatment
that slows the relentless progression of the neurodegenerative process. The concept of …