The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
F Lyko - Nature Reviews Genetics, 2018 - nature.com
The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …
Functions and mechanisms of epigenetic inheritance in animals
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …
RNA can be passed to the next generation through meiotic products (gametes) is long …
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has
opened the possibility that sperm may function by delivering additional paternal information …
opened the possibility that sperm may function by delivering additional paternal information …
Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
E Hervouet, P Peixoto, R Delage-Mourroux… - Clinical …, 2018 - Springer
Our current view of DNA methylation processes is strongly moving: First, even if it was
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation
Q Shen, Q Zhang, Y Shi, Q Shi, Y Jiang, Y Gu, Z Li, X Li… - Nature, 2018 - nature.com
Varieties of RNA modification form the epitranscriptome for post-transcriptional regulation. 5-
Methylcytosine (5-mC) is a sparse RNA modification in messenger RNA (mRNA) under …
Methylcytosine (5-mC) is a sparse RNA modification in messenger RNA (mRNA) under …
The role of RNA modifications in the regulation of tRNA cleavage
Transfer RNA (tRNA) have been harbingers of many paradigms in RNA biology. They are
among the first recognized noncoding RNA (ncRNA) playing fundamental roles in RNA …
among the first recognized noncoding RNA (ncRNA) playing fundamental roles in RNA …
Sleep deprivation and the epigenome
Sleep deprivation disrupts the lives of millions of people every day and has a profound
impact on the molecular biology of the brain. These effects begin as changes within a …
impact on the molecular biology of the brain. These effects begin as changes within a …
The emerging field of epitranscriptomics in neurodevelopmental and neuronal disorders
MT Angelova, DG Dimitrova, N Dinges… - … in bioengineering and …, 2018 - frontiersin.org
Analogous to DNA methylation and histone modifications, RNA modifications represent a
novel layer of regulation of gene expression. The dynamic nature and increasing number of …
novel layer of regulation of gene expression. The dynamic nature and increasing number of …
Signatures of DNA methylation across insects suggest reduced DNA methylation levels in Holometabola
It has been experimentally shown that DNA methylation is involved in the regulation of gene
expression and the silencing of transposable element activity in eukaryotes. The variable …
expression and the silencing of transposable element activity in eukaryotes. The variable …
Epigenetic control of gene regulation during development and disease: A view from the retina
Complex biological processes, such as organogenesis and homeostasis, are stringently
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …