[HTML][HTML] The rules and functions of nucleocytoplasmic shuttling proteins

X Fu, C Liang, F Li, L Wang, X Wu, A Lu, G Xiao… - International journal of …, 2018 - mdpi.com
Biological macromolecules are the basis of life activities. There is a separation of spatial
dimension between DNA replication and RNA biogenesis, and protein synthesis, which is …

Histone deacetylase inhibitors modulating non-epigenetic players: the novel mechanism for small molecule based therapeutic intervention

SA Ganai - Current drug targets, 2018 - ingentaconnect.com
Histone deacetylases (HDACs) play a crucial role in regulating the expression and activity of
myriad of proteins involved in tumour onset and progression. HDAC activity results in a …

Effects of the Mortalin Inhibitor MKT-077 on the Tumor Suppressor p53 in Neuroblastoma IMR-32 Cells

Y Ebrahim - 2018 - scholars.unh.edu
The tumor suppressor protein, p53, is an important cell cycle regulator in humans. Over half
of all human cancers involve disruption of p53 function. One way this is achieved is by …

[PDF][PDF] Regulation of p53 by Fam83F “family with sequence similarity 83F”

M Salama - 2018 - core.ac.uk
1. Introduction p53 was discovered in 1979 where it was found to co-precipitate with the
large T-antigen of simian virus 40 (SV40) in extracts of SV40-transformed cells (Kress et al …

The Role of TNF-Alpha, Beta, XRCC1 and p53 Gene Predisposition in Cancers

S Kollabathina, G Sudhakar - … & Review in …, 2018 - geographical.go2journals.com
Cancer is a group of diseases characterized by abnormal and uncontrolled cellular growth
and differentiation. The major cause of Cancer consists of different types of genetic …

The role of sphingosine kinases and dihydroceramide desaturase in regulating senescence in prostate cancer cells

M McNaughton - 2018 - stax.strath.ac.uk
Sphingosine kinase 1 and Sphingosine kinase 2 (SK1 and SK2) are lipid kinases which
form the bioactive lipid sphingosine-1-phosphate (S1P). SKs have been widely implicated in …