Solid lipid nanoparticle (SLN) delivery systems have a wide applicability in the delivery of
phyto-bioactive compounds to treat various chronic diseases, including diabetes, cancer …

Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving
complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical …

'Acridine'along with its functional analogue 'Acridone'is the most privileged pharmacophore
in medicinal chemistry with diverse applications ranging from DNA intercalators …

Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …

Resveratrol is a naturally occurring stilbene which has shown promising results as treatment
for several neurodegenerative diseases. However, its application is limited due to its low …

Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed
based on multi-target directed ligands (MTLDs) paradigm, synthesized and evaluated in …

A new series of sixteen multifunctional N-benzyl-piperidine-aryl-acylhydrazones hybrid
derivatives was synthesized and evaluated for multi-target activities related to Alzheimer's …

The multifactorial nature of Alzheimer's disease (AD) calls for the development of multitarget
agents addressing key pathogenic processes. A novel family of donepezil-butylated …

A series of novel tacrine-phenolic acid dihybrids and tacrine-phenolic acid-ligustrazine
trihybrids were synthesized, characterized and screened as novel potential anti-Alzheimer …

Acetylcholinesterase (AChE) is a critical enzyme, in Alzheimer's disease (AD) progression
and hence has been subjected to intense drug discovery programme. Here, we report …