A brave new world of RNA-binding proteins
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
RNA molecules can fold into intricate shapes that can provide an additional layer of control
of gene expression beyond that of their sequence. In this Review, we discuss the current …
of gene expression beyond that of their sequence. In this Review, we discuss the current …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Applications of deep learning and reinforcement learning to biological data
Rapid advances in hardware-based technologies during the past decades have opened up
new possibilities for life scientists to gather multimodal data in various application domains …
new possibilities for life scientists to gather multimodal data in various application domains …
Sequence, structure, and context preferences of human RNA binding proteins
D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
Cytoplasmic functions of long noncoding RNAs
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found
throughout the cell that lack protein‐coding function. Their functions are closely linked to …
throughout the cell that lack protein‐coding function. Their functions are closely linked to …
The role of m6A/m-RNA methylation in stress response regulation
Summary N 6-methyladenosine (m 6 A) and N 6, 2′-O-dimethyladenosine (m 6 Am) are
abundant mRNA modifications that regulate transcript processing and translation. The role …
abundant mRNA modifications that regulate transcript processing and translation. The role …
Alternative 3′ UTRs modify the localization, regulatory potential, stability, and plasticity of mRNAs in neuronal compartments
Neurons localize mRNAs near synapses where their translation can be regulated by
synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …
synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …
RMBase v2. 0: deciphering the map of RNA modifications from epitranscriptome sequencing data
More than 100 distinct chemical modifications to RNA have been characterized so far.
However, the prevalence, mechanisms and functions of various RNA modifications remain …
However, the prevalence, mechanisms and functions of various RNA modifications remain …
[HTML][HTML] Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1
Abstract Human hnRNP A2/B1 is an RNA-binding protein that plays important roles in many
biological processes, including maturation, transport, and metabolism of mRNA, and gene …
biological processes, including maturation, transport, and metabolism of mRNA, and gene …