Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Most secretory proteins travel through a well-documented conventional secretion pathway
involving the endoplasmic reticulum (ER) and the Golgi complex. However, recently, it has …

Despite its discovery more than three decades ago and well-established role in protein
sorting and trafficking in the early secretory pathway, the intermediate compartment (IC) has …

Defects in assembly of gap junction-forming proteins, called connexins (Cxs), are observed
in a variety of cancers. Connexin32 (Cx32; also known as GJB1) is expressed by the …

It has long been known that the gap junction is down-regulated in many tumours. One of the
downregulation mechanisms is the translocation of connexin, a gap junction protein, from …

Abstract The connexin 31 (Cx31) mutants L135V and L209F are linked to the skin disease
erythrokeratodermia variabilis et progressiva. We investigated the life-cycle of Cx31 and its …

Gap junctions (GJ) s are conglomeration of several cell-cell channels at cell-to-cell contact
sites involved in the direct intercellular exchange of small growth regulatory molecules …

Introduction: Connexins (Cxs), a large family of proteins, are expressed in numerous
mammalian cells. Cxs oligomerise into hexameric hemichannels in the plasma membrane …