Abstract The Industrial Revolution and the accompanying nutritional, epidemiological and
demographic transitions have profoundly changed human ecology and biology, leading to …

Sequence variants in the parental genomes that are not transmitted to a child (the proband)
are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …

Osteoarthritis is a common complex disease imposing a large public-health burden. Here,
we performed a genome-wide association study for osteoarthritis, using data across 16.5 …

We analyze whole-genome sequencing data from 141,431 Chinese women generated for
non-invasive prenatal testing (NIPT). We use these data to characterize the population …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Variation in reproductive lifespan and female fertility have implications for health, population
size and ageing. Fertility declines well before general signs of menopause and is also …

Abstract The Silk Road, which derives its name from the trade of silk produced by the
domestic silkworm Bombyx mori, was an important episode in the development and …

Social, cultural, economic, and biological factors are widely recognized as critical
determinants of well-being across the life course. Yet an integrative understanding of the …

Pedigree-based analyses of intelligence have reported that genetic differences account for
50–80% of the phenotypic variation. For personality traits these effects are smaller, with 34 …