β-Arrestin based receptor signaling paradigms: Potential therapeutic targets for complex age-related disorders

J Van Gastel, JO Hendrickx, H Leysen… - Frontiers in …, 2018 - frontiersin.org
G protein coupled receptors (GPCRs) were first characterized as signal transducers that
elicit downstream effects through modulation of guanine (G) nucleotide-binding proteins …

Importance of GPCR-mediated microglial activation in Alzheimer's disease

ME Haque, IS Kim, M Jakaria, M Akther… - Frontiers in cellular …, 2018 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
impairment of cognition, memory deficits and behavioral abnormalities. Accumulation of …