Designed to minimize chances of transferring genetically abnormal embryos,
preimplantation genetic diagnosis (PGD) involves in vitro fertilization (IVF), embryo biopsy …

Objective To assess whether embryonic DNA isolated from blastocyst culture conditioned
medium (BCCM) combined with blastocoel fluid (BF) could be used for blastocyst stage non …

Aim To select an optimal whole‐genome amplification (WGA) method to improve the
efficiency of the preimplantation genetic diagnosis and screening (PGD/PGS) of beta …

In this study, we aimed to assess the performance of two whole-genome amplification
methods, multiple displacement amplification (MDA), and multiple annealing and looping …

Single-cell genomics is an alluring area that holds the potential to change the way we
understand cell populations. Due to the small amount of DNA within a single cell, whole …

In families at risk from monogenic diseases affected offspring, it is fundamental the
development of a suitable Double Factor Preimplantation Genetic Testing (DF-PGT) method …

To allow multiple genetic analyses on a single cell, whole genome amplification (WGA) is
required. Unfortunately, studies comparing different WGA methods for downstream human …

Single Gene Disorders (SGD) are still routinely diagnosed using PCR-based assays that
need to be developed and validated for each individual disease-specific gene fragment. The …

Shallow whole genome sequencing has recently been introduced for genome-wide
detection of chromosomal copy number alterations (CNAs) in preimplantation genetic …

Genetic factors may be involved in the onset of neurodegenerative diseases like Alzheimer's
disease. In the case of the familial type, the disease is due to an inherited mutation at …