Beyond channel activity: protein-protein interactions involving viroporins
J To, J Torres - Virus Protein and Nucleoprotein Complexes, 2018 - Springer
Viroporins are short polypeptides encoded by viruses. These small membrane proteins
assemble into oligomers that can permeabilize cellular lipid bilayers, disrupting the …
assemble into oligomers that can permeabilize cellular lipid bilayers, disrupting the …
Network-guided discovery of influenza virus replication host factors
EE Ackerman, E Kawakami, M Katoh, T Watanabe… - MBio, 2018 - Am Soc Microbiol
The positions of host factors required for viral replication within a human protein-protein
interaction (PPI) network can be exploited to identify drug targets that are robust to drug …
interaction (PPI) network can be exploited to identify drug targets that are robust to drug …
An integrative approach to virus–host protein–protein interactions
Since cell regulation and protein expression can be dramatically altered upon infection by
viruses, studying the mechanisms by which viruses infect cells and the regulatory networks …
viruses, studying the mechanisms by which viruses infect cells and the regulatory networks …
Pharmacokinetic and pharmacodynamic evaluation of daclatasvir, asunaprevir plus beclabuvir as a fixed-dose co-formulation for the treatment of hepatitis C
I Esposito, S Marciano, J Trinks - Expert Opinion on Drug …, 2018 - Taylor & Francis
Introduction: Many reports have evaluated the clinical efficacy and safety of the fixed-dose
all-oral combination of daclatasvir, asunaprevir, and beclabuvir (DCV-TRIO), which was …
all-oral combination of daclatasvir, asunaprevir, and beclabuvir (DCV-TRIO), which was …
Leveraging Experimental Details for an Improved Understanding of Host‐Pathogen Interactome
M Ammari, F McCarthy… - Current protocols in …, 2018 - Wiley Online Library
An increasing proportion of curated host‐pathogen interaction (HPI) information is becoming
available in interaction databases. These data represent detailed, experimentally‐verified …
available in interaction databases. These data represent detailed, experimentally‐verified …
Defining Pharmacological Targets by Analysis of Virus–Host Protein Interactions
M Llano, MA Peña-Hernandez - … in protein chemistry and structural biology, 2018 - Elsevier
Viruses are obligate parasites that depend on cellular factors for replication.
Pharmacological inhibition of essential viral proteins, mostly enzymes, is an effective …
Pharmacological inhibition of essential viral proteins, mostly enzymes, is an effective …