The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

Specific metabolic programs are activated by immune cells to fulfill their functional roles,
which include adaptations to their microenvironment. B1 B cells are tissue-resident, innate …

Fibroblasts in secondary lymphoid organs, or fibroblastic reticular cells (FRC), are gate-
keepers of immune responses. Here, we frame how these cells regulate immune responses …

Objectives The utility of cerebrospinal fluid (CSF) CXCL13 for diagnosis of acute Lyme
neuroborreliosis (LNB) has been debated and the test is not yet routinely performed. This …

During brain development, the immune system mediates neurogenesis, gliogenesis and
synapse formation. However, it remains unclear whether peripheral lymphocytes contribute …

For decades, it has been known that the serous cavities, which include the peritoneal,
pleural and pericardial cavities, harbour large numbers of macrophages. In particular, due to …

During brain development, the generation of neurons and glial cells is rigorously regulated
by diverse mechanisms including the immune system. Dysfunction of the developing system …

The internal organs embedded in the cavities are lined by an epithelial monolayer termed
the mesothelium. The mesothelium is increasingly implicated in driving various internal …

Immune protection of the body cavities depends on the swift activation of innate and
adaptive immune responses in nonclassical secondary lymphoid organs known as fat …