Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1α and APC2 gene expression in non-small cell …
Background Dysregulated histone methyltransferase G9a may represent a potential cancer
therapeutic target. The roles of G9a in tumorigenesis and therapeutics are not well …
therapeutic target. The roles of G9a in tumorigenesis and therapeutics are not well …
Sulforaphane restores acetyl-histone H3 binding to Bcl-2 promoter and prevents apoptosis in ethanol-exposed neural crest cells and mouse embryos
Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables. SFN's
cytoprotective properties have been demonstrated in several models associated with a …
cytoprotective properties have been demonstrated in several models associated with a …
Nuclear actin polymerized by mDia2 confines centromere movement during CENP-A loading
Centromeres are specialized chromosomal regions epigenetically defined by the histone H3
variant centromere protein A (CENP-A). CENP-A needs to be replenished in every cell cycle …
variant centromere protein A (CENP-A). CENP-A needs to be replenished in every cell cycle …
Depletion of A‐type lamins and Lap2α reduces 53BP1 accumulation at UV‐induced DNA lesions and Lap2α protein is responsible for compactness of irradiated …
E Bártová, S Legartová, J Krejčí… - Journal of Cellular …, 2018 - Wiley Online Library
We studied how deficiency in lamins A/C and lamina‐associated polypeptide 2α (Lap2α)
affects DNA repair after irradiation. A‐type lamins and Lap2α were not recruited to local DNA …
affects DNA repair after irradiation. A‐type lamins and Lap2α were not recruited to local DNA …