An ageing myocardium possesses significant electrophysiological alterations that
predisposes the elderly patient to arrhythmic risk. Whilst these alterations are intrinsic to the …

Heart failure (HF) is associated with significant morbidity and mortality. The disease is
characterised by autonomic imbalance with increased sympathetic activity and withdrawal of …

Synaptic plasticity is defined as the ability of synapses to change their strength of
transmission. Plasticity of synaptic connections in the brain is a major focus of neuroscience …

Background Approximately half of the patients presenting with new‐onset heart failure (HF)
have HF with preserved left ventricular ejection fraction (HFpEF) and HF with mid‐range left …

Age-associated changes in cardiac structure and function have been observed from the
molecular to whole organ level in humans and mammalian models. Understanding the …

Afferent fibers expressing the vanilloid receptor 1 (VR1) channel have been implicated in
cardiac nociception; however, their role in modulating reflex responses to cardiac stress is …

Sympathetic and Parasympathetic Coactivation Induces Perturbed Heart Rate Dynamics in
Patients with Paroxysmal Atrial Fibrillation - PMC Back to Top Skip to main content NIH NLM …

Cardiac disease causes 33% of deaths worldwide but our knowledge of disease
progression is still very limited. In vitro models utilising and combining multiple, differentiated …

Cardiac sympathetic denervation (CSD) to treat ventricular arrhythmias (VAs) requires
transection at the middle or lower third of stellate (cervicothoracic) ganglia (SG). However …

The autonomic nervous system regulates multiple physiological functions; how distinct
neurons in peripheral autonomic and intrathoracic ganglia communicate remains to be …