Abstract Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO,
plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …

Control of cellular metabolism is critical for efficient cell function, although little is known
about the interplay between cell subset–specific metabolites in situ, especially in the tumor …

Iron is a chemical element that is active in the fundamental physiological processes for
human life, but its burden can be toxic to the body, mainly because of the stimulation of …

Metastasis is commonly seen in advanced stage of cancers, and matrix metalloproteinases
(MMPs) are commonly up-regulated and have been identified as critical regulators. In this …

Abstract Near-infrared (NIR, 740–780 nm) optogenetic systems are well-suited to spectral
multiplexing with blue-light-controlled tools. Here, we present two protocols, one for …

Arsenic (As) is a known toxic element and carcinogen. Transcription factor nuclear factor-
erythroid 2-related factor 2 (NRF2) controls cellular adaptation to oxidants and electrophiles …

Metastatic tumor cells engage the local tumor microenvironment and activate specific pro-
survival mechanisms to thrive and progress in the harsh bone marrow niche. Here we show …

Increasing numbers of cancer deaths worldwide demand for new treatment avenues. Cold
physical plasma is a partially ionized gas expelling a variety of reactive oxygen and nitrogen …

Background/Aims: Nuclear factor erythroid 2-related factor 2 (Nrf2) is an oncogene in
various types of cancers, including oral squamous cell carcinoma (OSCC) …

Abstract Heme oxygenase-1 (HO-1) has been implicated in tumor progression, but the
underlying molecular mechanisms remain largely unknown. Transforming growth factor-β1 …