Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease
characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma …

Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic,
progressive scarring of the lungs and the pathological hallmark of usual interstitial …

Endoplasmic reticulum (ER) stress is associated with development and progression of
fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). ER stress was first implicated …

Epithelial–mesenchymal transition (EMT) plays key roles during lung development and
many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer …

Background Idiopathic pulmonary fibrosis (IPF) risk has a strong genetic component. Studies
have implicated variations at several loci, including TERT, surfactant genes, and a single …

Endoplasmic Reticulum (ER) stress of alveolar epithelial cells (AECs) is recognized as a key
event of cell dysfunction in pulmonary fibrosis (PF). However, the mechanisms leading to …

Hippo/YAP signaling plays pleiotropic roles in the regulation of cell proliferation and
differentiation during organogenesis and tissue repair. Herein we demonstrate increased …

Respiratory distress syndrome (RDS) impacts a high proportion of preterm neonates,
resulting in significant morbidity and mortality. Advances in pharmacotherapy, specifically …