Owing to their tremendous diversity and plasticity, immune cells exert multifaceted functions
in tumor-bearing hosts, ranging from anti-tumor to pro-tumor activities. Tumor immune …

The programmed death protein 1 (PD-1) and its ligand (PD-L1) represent a well-
characterized immune checkpoint in cancer, effectively targeted by monoclonal antibodies …

DNA damage can be sensed as a danger-associated molecular pattern by the innate
immune system. Here we find that keratinocytes and other human cells mount an innate …

Purpose: Radiotherapy (RT) can transform the immune landscape and render poorly
immunogenic tumors sensitive to PD-L1 inhibition. Here, we established that the response to …

In response to varying stress signals, the p53 tumor suppressor is able to promote repair,
survival, or elimination of damaged cells–processes that have great relevance to organismal …

Although immunotherapy continues to demonstrate efficacy in a variety of refractory cancers,
currently, no any immunotherapeutic strategy is clinically used for gastric cancer (GC) except …

The tumor suppressive transcription factor p53 regulates a wide array of cellular processes
that confer upon cells an essential protection against cancer development. Wild-type p53 …

CD103+ dendritic cells are critical for cross-presentation of tumor antigens. Here we have
shown that during immunotherapy, large numbers of cells expressing CD103 arose in …

PD-L1, a key inhibitory immune receptor, has crucial functions in cancer immune evasion,
but whether PD-L1 promotes the malignant properties of cervical cancer (CC) cells and the …

Abstract p53 transcriptional networks are well-characterized in many organisms. However, a
global understanding of requirements for in vivo p53 interactions with DNA and relationships …