Many disease-causing missense mutations affect intrinsically disordered regions (IDRs) of
proteins, but the molecular mechanism of their pathogenicity is enigmatic. Here, we employ …

Animal bioreactors are genetically modified animal systems that have the potential to reduce
production cost, and improve production efficiency, of pharmaceutically relevant …

Despite the success of animal cloning by somatic cell nuclear transfer (SCNT) in many
species, the method is limited by its low efficiency. After zygotic genome activation (ZGA) …

N-Acetylaspartate (NAA) is the second most abundant organic metabolite in the brain, but its
physiological significance remains enigmatic. Toxic NAA accumulation appears to be the …

The protein tyrosine kinase Pyk2 is encoded by PTK2B, a novel Alzheimer's disease (AD)
susceptibility variant, with the PTK2B risk allele being associated with increased mRNA …

Abstract Rationale: Chitinase 3-like 1 (Chi3L1) protein is up-regulated in various diseases
including solid cancers. According to Genome-Wide Association Study (GWAS)/Online …

Spermatogenesis is a highly complex developmental process that occurs primarily in
seminiferous tubules of the testes and requires additional maturation steps in the epididymis …

Mammalian sperm evolutionarily acquired complex mechanisms to regulate their behaviors,
which are thought to be crucial in navigating through the female reproductive tract toward …

Introduction: Lesch-Nyhan syndrome is a clinical and laboratory disorder caused by X-linked
disruption of the purine metabolism. The deletion in the HPRT1 gene leads to the …

The technology of creating genetically modified animals (placental mammals) by
microinjection into the pronucleus of a fertilized egg suggests, as one of the key stages, the …