Respiratory viruses cause infections of the upper or lower respiratory tract and they are
responsible for the common cold—the most prevalent disease in the world. In many cases …

Inflammation and its resolution is under-studied in medicine despite being essential for
understanding the development of chronic inflammatory disease. In this review article, we …

Trillions of microbes inhabit the human gut, not only providing nutrients and energy to the
host from the ingested food, but also producing metabolic bioactive signaling molecules to …

Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making
key cell components. It is now clear that some of these metabolites also act as signals …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

A variety of innate immune responses and functions are dependent on time of day, and
many inflammatory conditions are associated with dysfunctional molecular clocks within …

The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2
also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an …

SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family
and localized in the plasma membrane of several body districts. ASCT2 is an acronym …

Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but
how systemic metabolism influences immune cell metabolism and function remains to be …

Increase in life-span is commonly related with age-related diseases and with gradual loss of
genomic, proteomic and metabolic integrity. Nrf2 (Nuclear factor-erythroid 2-p45 derived …