The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

The prevalence of diabetes is rapidly increasing and closely associated with cardiovascular
morbidity and mortality. While the major cardiovascular complication associated with …

Background: Redox signaling plays an important role in the lives of cells. This signaling not
only becomes apparent in pathologies but is also thought to be involved in maintaining …

Inflammation accompanies heart failure and is a mediator of cardiac fibrosis. CaMKIIδ plays
an essential role in adverse remodeling and decompensation to heart failure. We postulated …

Atrial remodelling involves electrophysiological and structural abnormalities that promote
the development and perpetuation of atrial fibrillation. Experimental and clinical data …

Heart contraction vitally depends on tightly controlled intracellular Ca regulation. Because
contraction is mainly driven by Ca released from the sarcoplasmic reticulum (SR), this …

Angiotensin II (Ang II) and inflammation are associated with pathogenesis of atrial fibrillation
(AF), but the underlying molecular mechanisms of these events remain unknown. The …

Atrial fibrillation (AF) is prevalent in hypertension and elevated angiotensin II (Ang II);
however, the mechanisms by which Ang II leads to AF are poorly understood. Here, we …

The precise mechanisms by which oxidative stress (OS) causes atrial fibrillation (AF) are not
known. Since AF frequently originates in the posterior left atrium (PLA), we hypothesized that …