Testicular cancer is the most common malignancy among men between 14 and 44 years of
age, and its incidence has risen over the past two decades in Western countries. Both …

The acquisition of cancer hallmarks requires molecular alterations at multiple levels
including genome, epigenome, transcriptome, proteome, and metabolome. In the past …

INTRODUCTION Cancer is one of the leading causes of death worldwide. Although the 2%
of the human genome that encodes proteins has been extensively studied, much remains to …

Epitranscriptomics has gained ground in recent years, especially after the advent of
techniques for accurately studying these mechanisms. Among all modifications occurring in …

Introduction: The central dogma of molecular biology, which states that the only role of long
RNA transcripts is to convey information from gene to protein, was brought into question in …

Multi-omic data provides multiple views of the same patients. Integrative analysis of multi-
omic data is crucial to elucidate the molecular underpinning of disease etiology. However …

Testicular germ cell tumors are unique among solid cancers. Historically, this disease was
deadly if progressed beyond the stage I. The implementation of cisplatin-based …

It is well established that cancer cells exhibit alterations in chromatin structure and
accessibility. Indeed, the dysregulation of many protein-coding players with enzymatic …

Testicular germ cell tumors (TGCT) are the most common cancer in the population of young
men [1]. Pioneering efforts of researchers and clinicians from the 1960s to the 1980s have …

Predicting developmental potency and risk of posttransplantation tumor formation by human
pluripotent stem cells (hPSCs) and their derivatives largely rely on classical histological …