Mitochondria are key cell organelles in that they are responsible for energy production and
control many processes from signalling to cell death. The function of the mitochondrial …

Ageing is the main risk factor for the development of cardiovascular diseases. A central
mechanism by which ageing promotes vascular pathologies is compromising endothelial …

INTRODUCTION Parkinson's disease (PD) is the second most common neurodegenerative
disorder. Intracellular protein aggregates composed primarily of α-synuclein lead to …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease.
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …

In this tribute to Solomon H. Snyder (Sol) we discuss the mechanisms by which nitric oxide
(NO) kills neurons. We provide a historical perspective regarding the discovery that …

Current drug development strategies devote extensive effort to identifying the molecular
mechanism of action of new drug candidates. Often, if more than one unrelated enzyme or …

Nicotinic acid and nicotinamide, collectively referred to as niacin, are nutritional precursors
of the bioactive molecules nicotinamide adenine dinucleotide (NAD) and nicotinamide …

Tuberculous meningitis is a serious, life-threatening disease affecting vulnerable
populations, including HIV-infected individuals and young children. The US National …

Background Although olaparib, the first poly (adenosine diphosphate [ADP]-ribose)
polymerase (PARP) inhibitor approved, has been used in routine clinical practice for over …

Exposure to air pollutants, such as particulate matter (PM), has been implicated in
neurodegenerative disorders including Alzheimer's disease (AD). However, direct effects of …