A spirocyclic, sp 3-atom rich oxetane-containing scaffold was synthesised in just two steps
via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be …

Heterobimetallic lanthanide–sodium alkoxides Ln2Na8 (OCH2CF3) 14 (THF) 6 catalyzed
the reaction of esters and amines to produce amides in up to 99% yields. They showed high …

Diazetidin‐3‐ones are readily accessible, small ring scaffolds that upon functionalization
have the potential to produce diverse 3‐dimensional structures for drug discovery. Thus …

A practical synthetic method for the direct synthesis of unsymmetrically substituted ureas
from N-Alloc-, N-Cbz-, and N-Boc-protected amines is described. In this study, efficient direct …

Stěžejním bodem diplomové práce byl vývoj syntézy vedoucí k potenciálně biologicky
aktivních derivátů pyrazolu, které mohou inhibovat cyklin-dependentní kinázy. Klíčovými …

With a growing desire to explore three-dimensional chemical space, methods for the
synthesis of spirocyclic compounds, more specifically aza-spirocycles, are becoming of …

With the formation of amide bonds being one of the most widely performed reactions within
organic chemistry, highly efficient and atom economical approaches enabling the …