Omega-3 fatty acids and non-alcoholic fatty liver disease: Evidence of efficacy and mechanism of action

E Scorletti, CD Byrne - Molecular aspects of medicine, 2018 - Elsevier
For many years it has been known that high doses of long chain omega-3 fatty acids are
beneficial in the treatment of hypertriglyceridaemia. Over the last three decades, there has …

Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease

DB Jump, KA Lytle, CM Depner, S Tripathy - Pharmacology & therapeutics, 2018 - Elsevier
Obese and type 2 diabetic (T2DM) patients have a high prevalence of nonalcoholic fatty liver
disease (NAFLD). NAFLD is a continuum of chronic liver diseases ranging from benign …

Is palmitoleic acid a plausible nonpharmacological strategy to prevent or control chronic metabolic and inflammatory disorders?

CO de Souza, GK Vannice… - Molecular Nutrition & …, 2018 - Wiley Online Library
Although dietary fatty acids can modulate metabolic and immune responses, the effects of
palmitoleic acid (16: 1n‐7) remain unclear. Since this monounsaturated fatty acid is …

Metaflammation: tissue-specific alterations of the NLRP3 inflammasome platform in metabolic syndrome

R Mastrocola, M Aragno, G Alloatti… - Current Medicinal …, 2018 - ingentaconnect.com
In the last decades, the extension of life expectancy and the increased consumption of foods
rich in saturated fats and added sugars have exposed the general population to emerging …

ELOVL4-mediated production of very long-chain ceramides stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

NM Kady, X Liu, TA Lydic, MH Syed, S Navitskaya… - Diabetes, 2018 - Am Diabetes Assoc
Tight junctions (TJs) involve close apposition of transmembrane proteins between cells.
Although TJ proteins have been studied in detail, the role of lipids is largely unknown. We …

Dominant ELOVL1 mutation causes neurological disorder with ichthyotic keratoderma, spasticity, hypomyelination and dysmorphic features

A Kutkowska-Kaźmierczak, M Rydzanicz… - Journal of medical …, 2018 - jmg.bmj.com
Background Ichthyosis and neurological involvement occur in relatively few known
Mendelian disorders caused by mutations in genes relevant both for epidermis and neural …

A High‐Fat Diet Rich in Saturated and Mono‐Unsaturated Fatty Acids Induces Disturbance of Thyroid Lipid Profile and Hypothyroxinemia in Male Rats

X Zhang, W Chen, S Shao, G Xu, Y Song… - Molecular nutrition & …, 2018 - Wiley Online Library
Scope Increasing evidence has shown that the disturbance of lipid metabolism might make
a possible contribution to the pathogenesis of organ dysfunction, including thyroid, yet it is …

Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned …

KFT Flister, BAS Pinto, LM França, CFF Coêlho… - The Journal of …, 2018 - Elsevier
Childhood consumption of added sugars, such as sucrose, has been associated to
increased risk of metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD) …

[HTML][HTML] Fatty acid elongase 5 (ELOVL5) alters the synthesis of long-chain unsaturated fatty acids in goat mammary epithelial cells

HB Shi, Y Du, CH Zhang, C Sun, YL He, YH Wu… - Journal of dairy …, 2018 - Elsevier
Increased production of long-chain unsaturated fatty acids (LCUFA) can have a positive
effect on the nutritional value of ruminant milk for human consumption. In nonruminant …

Effect of dietary polyunsaturated fatty acid and antioxidant supplementation on the transcriptional level of genes involved in lipid and energy metabolism in swine

M Vitali, C Dimauro, R Sirri, M Zappaterra… - PloS one, 2018 - journals.plos.org
Porcine fat traits depend mostly on the interaction between nutritional and genetic factors.
However, the pathways and biological processes influenced by this interaction are still …