This review covers basic aspects of histone modification and the role of posttranslational
histone modifications in the development of allergic diseases, including the immune …

Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

Oncogenesis is a multistep process mediated by a variety of factors including epigenetic
modifications. Global epigenetic post-translational modifications have been detected in …

Histone proteins constitute the core component of the nucleosome, the basic unit of
chromatin. Chemical modifications of histone proteins affect their interaction with genomic …

Objective: The development of obesity is inseparable from genetic and epigenetic factors,
and transcription factors (TFs) play an essential role in these two mechanisms. This review …

Histone acetyltransferase GCN5 is a critical component of the TGF‑β/Smad signaling
pathway in breast cancer cells; however, it remains unknown whether it is involved in the …

The posttranslational histone modifications that epigenetically affect gene transcription
extend beyond conventionally studied methylation and acetylation patterns. By examining …

Post-translational modifications of histones, such as acetylation and phosphorylation, are
highly conserved in eukaryotes and their combination enables precise regulation of many …

Gonadotropin-releasing hormone (GnRH) stimulates the expression of multiple genes in the
pituitary gonadotropes, most notably to induce synthesis of the gonadotropins, luteinizing …

Histone modifications provide an important layer of regulation for chromatin functions and
are critical for processes ranging from DNA replication to transcription, from cell-cycle …