Dry eye (DE) is a chronic ocular condition with high prevalence and morbidity. It has a
complex pathophysiology and is multifactorial in nature. Chronic ocular surface inflammation …

Purpose: We characterize age-associated alterations in the expression of inflammatory
mediators and tissue remodeling factors in human tears. Methods: A total of 75 consecutive …

Purpose While the normal cornea has limited innervation by the lymphatic system, chronic
immune-inflammatory disorders such as dry eye (DE) can induce lymphangiogenesis in the …

Purpose Cataract surgery can lead to the temporary development or worsening of dry eye
symptoms. Contributing factors may include corneal incisions, agents used before, during or …

Purpose: In several multicenter clinical trials, HLA-DR was found to be a potential biomarker
of dry eye disease (DED)'s severity and prognosis. Given the fact that HLA-DR receptor is a …

Purpose In this study, we examine the expression of corneal epithelium-derived
thrombospondin-1 (TSP-1) and its immunomodulatory functions in a validated murine model …

Dry eye is commonly treated with artificial tears; however, developing artificial tears similar
to natural tears is difficult due to the complex nature of tears. We characterized and …

Ocular inflammatory diseases, such as dry eye and uveitis, are common, painful, difficult to
treat, and may result in vision loss or blindness. Ocular side effects from the use of …

Purpose To compare the response of dry eye disease (DED) to treatment with topical steroid
in patients with and without graft-vs-host disease (GVHD). Design Post hoc analysis of a …

Purpose: To assess the effect of dry eye disease (DED) in graft donors on dendritic cell (DC)
maturation, host T-cell sensitization, and corneal allograft rejection. Methods: Corneas of …