Aniline-based inhibitors of influenza H1N1 virus acting on hemagglutinin-mediated fusion

R Leiva, M Barniol-Xicota, S Codony… - Journal of medicinal …, 2018 - ACS Publications
Two series of easily accessible anilines were identified as inhibitors of influenza A virus
subtype H1N1, and extensive chemical synthesis and analysis of the structure–activity …

Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers

R Musharrafieh, C Ma, J Wang - Antiviral research, 2018 - Elsevier
The majority of human influenza A viruses currently in circulation carry the amantadine-
resistant AM2-S31N channel mutation. We previously discovered a series of AM2-S31N …

Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7

YM Mandour, U Breitinger, C Ma, J Wang… - Drug Design …, 2018 - Taylor & Francis
Background Adamantane-based compounds have been identified to interfere with the ion-
channel activity of viroporins and thereby inhibit viral infection. To better understand the …

Reaction of Aldonitrones with N-Phenyl-9,10-dihydro-9,10-ethenoanthracene-11,12-dicarboximide

AP Molchanov, MM Efremova, AV Stepakov… - Russian Journal of …, 2018 - Springer
Thermal addition of aldonitrones (C, N-diaryl-and N-aryl-C-arylcarbamoylnitrones) to the
double bond of N-phenyl-9, 10-dihydro-9, 10-ethenoanthracene-11, 12-dicarboximide yields …

ВЗАИМОДЕЙСТВИЕ АЛЬДОНИТРОНОВ С А-ФЕНИЛИМИДОМ 9Д0-ДИГИДРО-9Д0-ЭТЕНОАНТРАЦЕН-ИД2-ДИКАРБОНОВОЙ КИСЛОТЫ

АП Молчанов, ММ Ефремова, АВ Степаков… - Журнал органической …, 2018 - elibrary.ru
Альдонитроны (С, N-диарил-и С-арил-N-арилкарбамоилнитроны) при нагревании
присоединяются по двойной связи N-фенилимида 9, 10-дигидро-9, 10-этеноантрацен …

[PDF][PDF] Molecular basis of inhibition and resistance of the influenza M2 ion channel by aminoadamantane drugs and discovery of novel resistance-breaking inhibitors …

TN Christina - 2018 - core.ac.uk
Amantadine (Amt (1)) and rimantadine (Rim (2)) are blockers of proton transport by influenza
A virus Μ2 ion channel protein, 1, 2 and approved as prophylactics and therapeutics against …