Is there a role for pharmacokinetic/pharmacodynamic-guided dosing for novel oral anticoagulants?

N Chan, PT Sager, J Lawrence, P Reilly… - American heart …, 2018 - Elsevier
The novel direct oral anticoagulants (NOACs) represent a major advance in oral
anticoagulant therapy and are replacing vitamin K antagonists as the preferred options for …

Two-year outcomes of anticoagulation for acute ischemic stroke with nonvalvular atrial fibrillation―SAMURAI-NVAF study―

S Yoshimura, M Koga, S Sato, K Todo… - Circulation …, 2018 - jstage.jst.go.jp
Background: We determined the 2-year long-term risk-benefit profile in patients with stroke
or transient ischemic attack (TIA) receiving warfarin or direct oral anticoagulants (DOACs) for …

Percutaneous left atrial appendage occlusion in the prevention of stroke in atrial fibrillation: a systematic review

JR Baman, M Mansour, EK Heist, DT Huang… - Heart Failure …, 2018 - Springer
Atrial fibrillation is commonly coexistent with heart failure, and the management of the heart
failure patient would be incomplete without an appreciation for atrial fibrillation …

Outcomes associated with warfarin time in therapeutic range among US veterans with nonvalvular atrial fibrillation

S Liu, X Li, Q Shi, M Hamilton, K Friend… - … medical research and …, 2018 - Taylor & Francis
Background: Poor quality of warfarin control (time in therapeutic range [TTR]< 65%) can lead
to increased risk of adverse events. The objective of this study was to examine the overall …

INR control of patients with mechanical heart valve on long-term warfarin therapy

CSY Tan, AYY Fong, YH Jong, TK Ong - Global heart, 2018 - Elsevier
Background Warfarin is an anticoagulant indicated for patients who had undergone
mechanical heart valve (s) replacement (MHVR). In these patients, time in therapeutic range …

Left atrial appendage exclusion during mitral valve surgery and stroke in atrial fibrillation

VA Abrich, AD Narichania, WT Love, LA Lanza… - Journal of Interventional …, 2018 - Springer
Purpose The purpose of this study was to determine whether surgical left atrial appendage
(LAA) exclusion performed during mitral valve surgery is associated with a reduction in …

Warfarin for prevention of thromboembolism in atrial fibrillation: comparison of patient characteristics and outcomes of the “Real-World” Michigan Anticoagulation …

AB Hughey, X Gu, B Haymart, E Kline-Rogers… - Journal of thrombosis …, 2018 - Springer
Randomized controlled trials (RCTs) examining warfarin use for stroke prevention in atrial
fibrillation (AF) may not accurately reflect real-world populations. We aimed to determine the …

Dedicated warfarin care programme results in superior warfarin control in Queensland, Australia

N Bernaitis, T Badrick… - International Journal of …, 2018 - Wiley Online Library
Background Warfarin is used to prevent stroke in patients with atrial fibrillation (AF). Ongoing
monitoring of International normalised ratio (INR) and time in therapeutic range (TTR) …

[HTML][HTML] Combination of catheter ablation for non‑valvular atrial fibrillation and left atrial appendage occlusion in a single procedure

X Li, J Li, H Chu, L Wang, L Shi… - Experimental and …, 2018 - spandidos-publications.com
Patients with atrial fibrillation (AF) have an increased risk of stroke and systemic embolism.
Catheter ablation (CA) is increasingly applied for the treatment for drug‑refractory AF; …

Relation of quality of anticoagulation control with different management systems among patients with atrial fibrillation: Data from FANTASIIA Registry

I Roldan Rabadan, MA Esteve‐Pastor… - European Journal of …, 2018 - Wiley Online Library
Background Anticoagulation control in patients with atrial fibrillation (AF) has a
multidisciplinary approach although is usually managed by general practitioners (GP) or …