Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics

MS Islam, A Ciavattini, F Petraglia… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma

R Huang, EK Rofstad - Journal of Experimental & Clinical Cancer …, 2018 - Springer
Integrins are a large family of adhesion molecules that mediate cell-cell and cell-
extracellular matrix interactions. Among the 24 integrin isoforms, many have been found to …

The RTK interactome: overview and perspective on RTK heterointeractions

MD Paul, K Hristova - Chemical reviews, 2018 - ACS Publications
Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation,
and survival. These single-pass membrane proteins are grouped into subfamilies based on …

The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration

SJ Atkinson, AM Gontarczyk, AAA Alghamdi… - EMBO …, 2018 - embopress.org
Integrin β3 is seen as a key anti‐angiogenic target for cancer treatment due to its expression
on neovasculature, but the role it plays in the process is complex; whether it is pro‐or anti …

Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis …

H Bazzazi, Y Zhang, M Jafarnejad, AS Popel - Journal of theoretical biology, 2018 - Elsevier
Cooperation between VEGFR2 and integrin αVβ3 is critical for neovascularization in wound
healing, cardiovascular ischemic diseases, ocular diseases, and tumor angiogenesis. In the …

Vascularization and angiogenesis in electrospun tissue engineered constructs: towards the creation of long-term functional networks

N Goonoo - Biomedical Physics & Engineering Express, 2018 - iopscience.iop.org
Despite unprecedented advancement in the field of tissue engineering (TE), only a few
engineered tissues-namely skin, cartilage and bladder-have achieved clinical success …

The use of polysulfated polysaccharides heparin like compounds, glycosaminoglycans and Vitamin B17 as a possible treatment for prostate cancer

J Hantash - Medical hypotheses, 2018 - Elsevier
Prostate cancer is impacting many men globally. It is a disease that has no effective
treatment is available in the market. The understanding of the biophysical and biochemical …

The role of the Integrin β3 Adhesome in Angiogenesis

S Atkinson - 2018 - ueaeprints.uea.ac.uk
Angiogenesis, the formation of new blood vessels from those that already exist, plays an
essential role in development, homeostasis and tumour growth. As such, targeting …

Analyse du site d'implantation de produits de thérapie cellulaire dans un modèle d'ischémie des membres inférieurs

R Al-Rifai - 2018 - hal.science
L'artériopathie oblitérante des membres inférieurs (AOMI) est une affection vasculaire
obstructive athéroscléreuse. Elle touche 20% des plus de 70 ans. L'ischémie critique des …

Role of stromal Caveolin-1 in breast cancer angiogenesis

A Diez Sanchez - 2018 - repisalud.isciii.es
Tumors have been described as “wounds that never heal”; and non-tumoral surrounding cell
populations involved in angiogenesis and response to injury, such as endothelial cells …