Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse lung injury,
which results in increased pulmonary vascular permeability and loss of aerated lung tissue …

Rationale: Esophageal manometry is the clinically available method to estimate pleural
pressure, thus enabling calculation of transpulmonary pressure (Pl). However, many …

Rationale: In acute respiratory distress syndrome (ARDS), atelectatic solid-like lung tissue
impairs transmission of negative swings in pleural pressure (Ppl) that result from …

Despite the recognition of its iatrogenic potential, mechanical ventilation remains the
mainstay of respiratory support for patients with acute respiratory distress syndrome (ARDS) …

Background Assessing alveolar recruitment at different positive end-expiratory pressure
(PEEP) levels is a major clinical and research interest because protective ventilation implies …

Objective: It is known that ventilator-induced lung injury causes increased pulmonary
inflammation. It has been suggested that one of the underlying mechanisms may be strain …

Tidal volume (VT) has been considered the main determinant of ventilator-induced lung
injury (VILI). Recently, experimental studies have suggested that mechanical power …

Background The use of positive end-expiratory pressure (PEEP) and prone position (PP) is
common in the management of severe acute respiratory distress syndrome patients (ARDS) …

Spontaneous breathing during mechanical ventilation balances important advantages
including improved oxygenation [1] and less diaphragm disuse [2] against serious …

Rationale: It remains unclear how prone positioning improves survival in acute respiratory
distress syndrome. Using serial computed tomography (CT), we previously reported that …