Testicular cancer is the most common malignancy among men between 14 and 44 years of
age, and its incidence has risen over the past two decades in Western countries. Both …

Tremendous progress in treatment and outcomes has been achieved across the whole
range of haematological malignancies in the past two decades. Although cure rates for …

We developed a likelihood-based approach for analyzing summary-level statistics and
external linkage disequilibrium information to estimate effect-size distributions of common …

Compared with all other racial and ethnic groups in the United States, African Americans are
disproportionally affected by lung cancer, both in terms of incidence and survival. It is likely …

Prostate cancer (CaP) is the most commonly diagnosed non-cutaneous cancer and the
second leading cause of male cancer deaths in the United States. Among African American …

Background Family history of bladder cancer confers an increased risk for concordant and
discordant cancers in relatives. However, previous studies investigating this relationship …

Genome-wide association studies have shown that pleiotropy is a common phenomenon
that can potentially be exploited for enhanced detection of susceptibility loci. We propose …

Motivation Genome-wide association studies are now shifting focus from analysis of
common to rare variants. As power for association testing for individual rare variants may …

Background: There exists compelling evidence that some genetic variants are associated
with the risk of multiple cancer sites (ie, pleiotropy). However, the biological mechanisms …

Background Chronic lymphocytic leukaemia (CLL) is 10-to 20-fold less common in Asians
(including Han Chinese) compared with persons of predominately European descent. Why …