The metabolism of endothelial cells (ECs) has only recently been recognized as a driving
force of angiogenesis. Metabolic pathways, such as glycolysis, fatty acid oxidation, and …

Dysregulation of cancer cell metabolism contributes to abnormal cell growth, the biological
end point of cancer. We review here numerous affected oncogenes and metabolic pathways …

Using a functional model of breast cancer heterogeneity, we previously showed that clonal
sub-populations proficient at generating circulating tumour cells were not all equally capable …

Defining the metabolic limitations of tumour growth will help to develop cancer therapies.
Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that …

When mammalian cells are deprived of glutamine, exogenous asparagine rescues cell
survival and growth. Here we report that this rescue results from use of asparagine in protein …

Numerous mechanisms to support cells under conditions of transient nutrient starvation
have been described. Several functions of the tumor-suppressor protein p53 can contribute …

KRAS is a regulator of the nutrient stress response in non-small-cell lung cancer (NSCLC).
Induction of the ATF4 pathway during nutrient depletion requires AKT and NRF2 …

General control nonderepressible 2 (GCN2) plays a major role in the cellular response to
amino acid limitation. Although maintenance of amino acid homeostasis is critical for tumor …

Nutrient restriction reprograms cellular signaling and metabolic network to shape cancer
phenotype. Lactate dehydrogenase A (LDHA) has a key role in aerobic glycolysis (the …

Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is
a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding …