Key pathways and regulators of vitamin K function and intermediary metabolism
MJ Shearer, T Okano - Annual review of nutrition, 2018 - annualreviews.org
Vitamin K (VK) is an essential cofactor for the post-translational conversion of peptide-bound
glutamate to γ-carboxyglutamate. The resultant vitamin K–dependent proteins are known or …
glutamate to γ-carboxyglutamate. The resultant vitamin K–dependent proteins are known or …
[HTML][HTML] VKORC1L1, an enzyme mediating the effect of vitamin K in liver and extrahepatic tissues
J Lacombe, M Ferron - Nutrients, 2018 - mdpi.com
Vitamin K is an essential nutrient involved in the regulation of blood clotting and tissue
mineralization. Vitamin K oxidoreductase (VKORC1) converts vitamin K epoxide into …
mineralization. Vitamin K oxidoreductase (VKORC1) converts vitamin K epoxide into …
[HTML][HTML] VKOR paralog VKORC1L1 supports vitamin K–dependent protein carboxylation in vivo
J Lacombe, MA Rishavy, KL Berkner, M Ferron - JCI insight, 2018 - ncbi.nlm.nih.gov
Vertebrates possess 2 proteins with vitamin K oxidoreductase (VKOR) activity: VKORC1,
whose vitamin K reduction supports vitamin K–dependent (VKD) protein carboxylation, and …
whose vitamin K reduction supports vitamin K–dependent (VKD) protein carboxylation, and …
Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase
MA Rishavy, KW Hallgren, L Wilson… - Blood, The Journal …, 2018 - ashpublications.org
The anticoagulant warfarin inhibits the vitamin K oxidoreductase (VKORC1), which
generates vitamin K hydroquinone (KH2) required for the carboxylation and consequent …
generates vitamin K hydroquinone (KH2) required for the carboxylation and consequent …
VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites
KJ Czogalla, K Liphardt, K Höning, V Hornung… - Blood …, 2018 - ashpublications.org
Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2, 3-epoxide reductase
complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo …
complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo …
The Vitamin K Epoxide Reductase Vkorc1l1 Promotes Preadipocyte Differentiation in Mice
Objective Identification of novel regulators involved in adipose development is important to
understand the molecular mechanism underlying obesity and associated metabolic …
understand the molecular mechanism underlying obesity and associated metabolic …
Genetic Polymorphism of VKORC1-1639 in Children With Intracranial Hemorrhage Due to Vitamin K Deficiency
U Berber, MA Özdemir, E Unal… - Clinical and Applied …, 2018 - journals.sagepub.com
Intracranial hemorrhage due to vitamin K deficiency is a serious disease that can lead to
morbidity, mortality, and mental retardation. Our goal in this study is to determine the …
morbidity, mortality, and mental retardation. Our goal in this study is to determine the …
Association between Vitamin K Epoxide Reductase (VKORC1)-1639G> A Polymorphism and Osteoporosis in Postmenopausal Women
F Kutluturk, A Inanir, A Rustemoglu… - … Metabolic & Immune …, 2018 - ingentaconnect.com
Introductıon: Osteoporosis is a common disease, and several factors contribute to its
development. Recently, there has been increasing evidence that vitamin K (VK) plays a …
development. Recently, there has been increasing evidence that vitamin K (VK) plays a …