Characterization of the neurochemical and behavioral effects of solriamfetol (JZP-110), a selective dopamine and norepinephrine reuptake inhibitor
MG Baladi, MJ Forster, MB Gatch, RB Mailman… - … of Pharmacology and …, 2018 - ASPET
Excessive sleepiness (ES) is associated with several sleep disorders, including narcolepsy
and obstructive sleep apnea (OSA). A role for monoaminergic systems in treating these …
and obstructive sleep apnea (OSA). A role for monoaminergic systems in treating these …
Multiple daytime administration of the selective orexin-2 receptor antagonist JNJ-42847922 induces somnolence in healthy subjects without residual central effects
PD van der Ark, G Golor, L van Nueten… - Journal of …, 2018 - journals.sagepub.com
Background: Pharmacokinetics, pharmacodynamics and general safety and tolerability of
JNJ-42847922, a selective orexin-2 receptor antagonist, were assessed in healthy subjects …
JNJ-42847922, a selective orexin-2 receptor antagonist, were assessed in healthy subjects …
[HTML][HTML] 食欲素受体拮抗剂治疗失眠症研究进展
黎越丹， 崔冬晓， 孙彦， 贾艳艳， 王平安 - 药学学报, 2018 - html.rhhz.net
发现于1998 年的食欲素体系(orexin system), 包括两个G-蛋白偶联受体(G-protein coupled
receptors, GPCRs): 食欲素-1 受体(orexin-1 receptor, OX 1 R) 和食欲素-2 受体(orexin-2 …
receptors, GPCRs): 食欲素-1 受体(orexin-1 receptor, OX 1 R) 和食欲素-2 受体(orexin-2 …
[PDF][PDF] Synthesis of Azulene-Based Compounds for Targeting Orexin Receptors
TO Leino - 2018 - helda.helsinki.fi
Orexin peptides, orexin-A and orexin-B, and orexin receptor 1 and orexin receptor 2 form the
orexin signaling system. The most studied part of the orexin system is its key role in sleep …
orexin signaling system. The most studied part of the orexin system is its key role in sleep …
Combination therapy
KDG Pfleger, E McCall, J Williams - US Patent 10,058,555, 2018 - Google Patents
2004-093527 2010-540527 A 96/40258 WO 00/25134 WO 04/022786 WO 05/050182 WO
05/031309 2006/029349 2008/000421 2008/055313 2008/060621 WO 08/055313 …
05/031309 2006/029349 2008/000421 2008/055313 2008/060621 WO 08/055313 …