Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
U Testa, E Pelosi, G Castelli - Medical Sciences, 2018 - mdpi.com
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
CD133-directed CAR T cells for advanced metastasis malignancies: A phase I trial
Y Wang, M Chen, Z Wu, C Tong, H Dai, Y Guo… - …, 2018 - Taylor & Francis
Expressed by cancer stem cells of various epithelial cell origins, CD133 is an attractive
therapeutic target for cancers. Autologous chimeric antigen receptor-modified T-cell directed …
therapeutic target for cancers. Autologous chimeric antigen receptor-modified T-cell directed …
[HTML][HTML] Single-cell transcriptomics characterizes cell types in the subventricular zone and uncovers molecular defects impairing adult neurogenesis
V Zywitza, A Misios, L Bunatyan, TE Willnow… - Cell reports, 2018 - cell.com
Neural stem cells (NSCs) contribute to plasticity and repair of the adult brain. Niches
harboring NSCs regulate stem cell self-renewal and differentiation. We used comprehensive …
harboring NSCs regulate stem cell self-renewal and differentiation. We used comprehensive …
IGF2 induces CD133 expression in esophageal cancer cells to promote cancer stemness
WW Xu, B Li, JF Zhao, JG Yang, JQ Li, SW Tsao… - Cancer letters, 2018 - Elsevier
Failure to eradicate cancer stem cells (CSC) during primary therapy may lead to cancer
recurrence. We recently reported that CD133 is a functional biomarker for CSCs in …
recurrence. We recently reported that CD133 is a functional biomarker for CSCs in …
Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells
Y Tang, J Berlind, N Mavila - Cell communication and signaling, 2018 - Springer
Background The WNT-beta-catenin pathway is known to regulate cellular homeostasis
during development and tissue regeneration. Activation of WNT signaling increases the …
during development and tissue regeneration. Activation of WNT signaling increases the …
Surface markers of human embryonic stem cells: a meta analysis of membrane proteomics reports
Introduction: Human embryonic stem cells (hESCs) have unique biological features and
attributes that make them attractive in various areas of biomedical research. With heightened …
attributes that make them attractive in various areas of biomedical research. With heightened …
Prominin-1/CD133: lipid raft association, detergent resistance, and immunodetection
J Karbanová, A Lorico, M Bornhäuser… - Stem cells …, 2018 - academic.oup.com
The cell surface antigen prominin-1 (alias CD133) has gained enormous interest in the past
2 decades and given rise to debates as to its utility as a biological stem and cancer stem cell …
2 decades and given rise to debates as to its utility as a biological stem and cancer stem cell …
Monoubiquitination of cancer stem cell marker CD133 at lysine 848 regulates its secretion and promotes cell migration
F Yang, Y Xing, Y Li, X Chen, J Jiang… - Molecular and Cellular …, 2018 - Taylor & Francis
ABSTRACT CD133, a widely known marker of cancer stem cells, was recently found in
extracellular vesicles. However, the mechanisms underlying CD133 translocation to the …
extracellular vesicles. However, the mechanisms underlying CD133 translocation to the …
Regeneration of the fallopian tube mucosa using bone marrow mesenchymal stem cell transplantation after induced chemical injury in a rat model
SM Almasry, AK Elfayomy… - Reproductive …, 2018 - journals.sagepub.com
In this study, we describe a novel insight about the use of bone marrow–derived
mesenchymal stem cells (BM-MSCs) for fallopian tube (FT) regeneration. Seventy rats' tubes …
mesenchymal stem cells (BM-MSCs) for fallopian tube (FT) regeneration. Seventy rats' tubes …
Hypomyelination and cognitive impairment in mice lacking CD133 (Prominin-1)
The CD133 antigen, also known as prominin-1, is a glycoprotein that specifically localizes to
plasma membrane protrusions. The precise function of CD133 remains unknown, but it is …
plasma membrane protrusions. The precise function of CD133 remains unknown, but it is …