Treatment and biology of pediatric acute lymphoblastic leukemia

M Kato, A Manabe - Pediatrics International, 2018 - Wiley Online Library
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. In the past
ALL was intractable but now the survival probability is as high as 80–90%. Improved …

Thymic stromal lymphopoietin isoforms, inflammatory disorders, and cancer

G Varricchi, A Pecoraro, G Marone… - Frontiers in …, 2018 - frontiersin.org
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a
murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity …

Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group

KG Roberts, SC Reshmi, RC Harvey… - Blood, The Journal …, 2018 - ashpublications.org
Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL; BCR-ABL1–like
ALL) in children with National Cancer Institute (NCI) intermediate-or high-risk (HR) ALL is …

[HTML][HTML] Advances in B-cell precursor acute lymphoblastic leukemia genomics

C Schwab, CJ Harrison - Hemasphere, 2018 - journals.lww.com
In childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), cytogenetic
abnormalities remain important diagnostic and prognostic tools. A number of well …

Genomics and pharmacogenomics of pediatric acute lymphoblastic leukemia

C Wu, W Li - Critical reviews in oncology/hematology, 2018 - Elsevier
Acute lymphoblastic leukaemia (ALL) is a prevalent form of pediatric cancer that accounts for
70–80% of all leukemias. Genome-based analysis, exome sequencing, transcriptomics and …

Mut2Vec: distributed representation of cancerous mutations

S Kim, H Lee, K Kim, J Kang - BMC medical genomics, 2018 - Springer
Background Embedding techniques for converting high-dimensional sparse data into low-
dimensional distributed representations have been gaining popularity in various fields of …

Chimeric antigen receptor T-cells for the treatment of B-cell acute lymphoblastic leukemia

C Tomuleasa, S Fuji, C Berce, A Onaciu… - Frontiers in …, 2018 - frontiersin.org
Chimeric antigen receptor (CAR) T-cell technology has seen a rapid development over the
last decade mostly due to the potential that these cells may have in treating malignant …

[HTML][HTML] Advances in biology of acute lymphoblastic leukemia (ALL) and therapeutic implications

M Mohseni, H Uludag, JM Brandwein - American journal of blood …, 2018 - ncbi.nlm.nih.gov
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer and also occurs in
adults. Although the outcomes of multi-agent chemotherapy regimens have greatly …

Acute lymphoblastic leukemia and lymphoblastic lymphoma in adolescents and young adults

JL McNeer, A Bleyer - Pediatric blood & cancer, 2018 - Wiley Online Library
Compared to younger and older age groups, the incidence of acute lymphoblastic leukemia
(ALL) and lymphoblastic lymphoma (LBL) has increased more in the adolescent and young …

Recent advances in the biology and treatment of B-cell acute lymphoblastic leukemia

M Hefazi, MR Litzow - Blood and lymphatic cancer: targets and …, 2018 - Taylor & Francis
Acute lymphoblastic leukemia (ALL) is a hematologic malignancy arising from precursors of
the lymphoid lineage. Conventional cytotoxic chemotherapies have resulted in high cure …