Faithful transmission of genetic material is crucial for all organisms since changes in genetic
information may result in genomic instability that causes developmental disorders and …

DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful
duplication of our genomes, mechanisms have evolved to deal with damage encountered …

Background DNA replication plays an important role in mutagenesis, yet little is known about
how it interacts with other mutagenic processes. Here, we use somatic mutation signatures …

Accurate completion of genome duplication is threatened by multiple factors that hamper the
advance and stability of the replication forks. Cells need to tolerate many of these blocking …

DNA damage tolerance (DDT) mechanisms facilitate replication resumption and completion
when DNA replication is blocked by bulky DNA lesions. In budding yeast, template switching …

HMGB proteins are involved in structural rearrangements caused by regulatory chromatin
remodeling factors. Particular interest is attracted to a DNA chaperone mechanism …

Cells expend a large amount of energy to maintain their DNA sequence. DNA repair
pathways, cell cycle checkpoint activation, proofreading polymerases, and chromatin …

HMGB-белки участвуют в структурных перестройках хроматина, вызванных факторами
его ремоделирования. Особенно интересен ДНК-шапероновый механизм, согласно …

Cells expend a large amount of energy to maintain their DNA sequence. DNA repair
pathways, cell cycle checkpoint activation, proofreading polymerases, and chromatin …

DNA replication stress poses a significant threat to the genome integrity of actively dividing
cells and is observed in many pathological human disorders. Replication stress is caused by …