Introduction: While the media is engaged and fascinated by the idea of 'Precision Medicine',
the nuances related to 'Precision Dosing'seem to be largely ignored. Assuming the 'right …

Background Escitalopram is used for post-partum depression; however, there are limited
pharmacokinetic data of escitalopram in milk and plasma of infants breastfed by women …

Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic
pathways and are classified in various superfamilies. The CYP, or P450, superfamily …

Formation of dextrorphan (DXT) from dextromethorphan (DXM) has been widely used to
assess cytochrome P450 2D (CYP2D) activity. Additionally, the kinetics of CYP2D activity …

The health benefits of breastfeeding are numerous and well described. It has been reported
that∼ 70% of women take medication in the postpartum period; however, little is known …

Sex differences in cancer occurrence and mortality are evident across tumor types; men
exhibit higher rates of incidence and often poorer responses to treatment. Targeted …

The concept of precision or personalized medicine in pediatrics is still in its infancy, and due
to ethical and logistical constraints, it is difficult to conduct clinical studies in pediatric to …

Pharmacokinetic variability is an important consideration in pharmacotherapy to ensure
safety and efficacy of medications, thus the understanding of the sources of variability in …