Benefits and health implications of testosterone therapy in men with testosterone deficiency

AM Traish - Sexual medicine reviews, 2018 - academic.oup.com
Abstract Introduction Testosterone (T) deficiency (TD; hypogonadism) has deleterious effects
on men's health; negatively affects glycometabolic and cardiometabolic functions, body …

Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials

BB Yeap, ST Page, M Grossmann - The Lancet Diabetes & …, 2018 - thelancet.com
A decrease in the concentration of circulating testosterone in many older men is a biomarker
and possibly a rectifiable contributing factor to ill health. Low circulating testosterone …

Ischemic stroke across sexes: What is the status quo?

L Liberale, F Carbone, F Montecucco… - Frontiers in …, 2018 - Elsevier
Stroke prevalence is expected to increase in the next decades due to the aging of the
Western population. Ischemic stroke (IS) shows an age-and sex-dependent distribution in …

Progressive impairment of testicular endocrine function in ageing men: testosterone and dihydrotestosterone decrease, and luteinizing hormone increases, in men …

BB Yeap, L Manning, SAP Chubb… - Clinical …, 2018 - Wiley Online Library
Context Sex hormone trajectories in ageing men and their health implications remain
unclear. We examined longitudinal trajectories and associations of testosterone (T) …

[HTML][HTML] Testosterone, myocardial function, and mortality

VE Bianchi - Heart failure reviews, 2018 - Springer
The cardiovascular system is particularly sensitive to androgens, but some controversies
exist regarding the effect of testosterone on the heart. While among anabolic abusers, cases …

Men sustain higher dysregulation levels than women without becoming frail

AA Cohen, V Legault, Q Li, LP Fried… - The Journals of …, 2018 - academic.oup.com
The aging process differs in important ways between the sexes, with women living longer
but at higher risk for frailty (the male–female health-survival paradox). The underlying …

Individual testosterone decline and future mortality risk in men

SA Holmboe, NE Skakkebæk, A Juul… - European Journal of …, 2018 - academic.oup.com
Objective Male aging is characterized by a decline in testosterone (TS) levels with a
substantial variability between subjects. However, it is unclear whether differences in age …

[HTML][HTML] Endogenous testosterone and mortality risk

EJ Meyer, G Wittert - Asian Journal of Andrology, 2018 - journals.lww.com
In men, obesity and metabolic complications are associated with lower serum testosterone
(T) and dihydrotestosterone (DHT) and an increased risk of, and mortality from, multiple …

[HTML][HTML] Testosterone and its metabolites: differential associations with cardiovascular and cerebrovascular events in men

BB Yeap - Asian journal of andrology, 2018 - journals.lww.com
As men grow older, circulating testosterone declines while the incidence of cardiovascular
disease increases. Thus, the role of sex hormones as biomarkers, and possibly contributing …

Evaluating calculated free testosterone as a predictor of morbidity and mortality independent of testosterone for cross-sectional and 5-year longitudinal health …

B Hsu, RG Cumming, FM Blyth… - The Journals of …, 2018 - academic.oup.com
To determine whether calculated free testosterone (cFT) provides prognostic information
independent of serum T for predicting morbidity and mortality in older men in cross-sectional …