The locus coeruleus (LC) contains norepinephrine (NE)-synthesizing neurons that send
diffuse projections throughout the central nervous system. The LC-NE system has a major …

Frontotemporal lobar degeneration causes a spectrum of complex degenerative disorders
including frontotemporal dementia, progressive supranuclear palsy and corticobasal …

Inhibitory control requires precise regulation of activity and connectivity within multiple brain
networks. Previous studies have typically evaluated age-related changes in regional activity …

Noradrenergic dysfunction contributes to cognitive impairment in Alzheimer's Disease (AD)
and Parkinson's Disease (PD). Conventional therapeutic strategies seek to enhance …

Highlights•Apathy and impulsivity are common consequences of frontotemporal lobar
degeneration syndromes.•Common frontostriatal loops mediate different modes of apathy …

Impulse control disorders (ICD) are common neuropsychiatric disorders that can arise in
Parkinson's disease (PD) patients after commencing dopamine replacement therapy …

Objective To investigate whether white matter microstructural changes can be used as a
predictor of worsening of motor features or cognitive decline in patients with Parkinson's …

Dopaminergic medications improve the motor symptoms of Parkinson's disease (PD), but
their effect on response inhibition, a critical executive function, remains unclear. Previous …

Background Atomoxetine selectively inhibits the reuptake of norepinephrine. Given the
noradrenergic system's role in executive function, pharmacotherapy options that affect …

Objective To identify the white matter correlates of apathy and impulsivity in the major
syndromes associated with frontotemporal lobar degeneration, using diffusion-weighted …