Results from preclinical rodent studies during the last 20 years implicated glutamate
neurotransmission in different brain regions in drug self-administration and rodent models of …

Abstract Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-
administration and reinstatement of drug-seeking behavior. However, the cellular and …

Relapse of drug abuse after abstinence is a major challenge to the treatment of addicts.
Thioredoxin-1 (Trx-1) is an important regulator of neuroprotection, and inhibits morphine …

En Chile, el consumo de pasta base de cocaína (PBC), una sustancia altamente tóxica y
adictiva, se ha convertido en un serio problema médico y social en las áreas más pobres …

РЕЗЮМЕ Проведенный анализ литературы, посвященной нейровизуальной картине
головного мозга пациентов с наркотической зависимостью, позволяет сделать вывод о …

Cocaine addiction is a chronic mental illness affecting a small subgroup of cocaine users
(approx. 18%). Little efforts have been taken so far to understand individual differences in …

Background Cocaine addiction is a major public health problem. Despite decades of intense
research, no effective treatments are available. Both preclinical and clinical studies of drug …

Surgical treatment for addiction has been proposed after the successful efficacy of deep
brain stimulation (DBS) for the treatment of neurological movement disorders such as …

Results MPEP inhibits cocaine self-administration and cocaine-induced reinstatement of
drug-seeking behavior. We have recently reported that the mGluR5 antagonists MTEP …