Cancer-associated thrombosis: an overview of mechanisms, risk factors, and treatment
NB Abdol Razak, G Jones, M Bhandari, MC Berndt… - Cancers, 2018 - mdpi.com
Cancer-associated thrombosis is a major cause of mortality in cancer patients, the most
common type being venous thromboembolism (VTE). Several risk factors for developing …
common type being venous thromboembolism (VTE). Several risk factors for developing …
The tumour glyco-code as a novel immune checkpoint for immunotherapy
E RodrÍguez, STT Schetters, Y van Kooyk - Nature Reviews …, 2018 - nature.com
Tumour growth is accompanied by tumour evasion of the immune system, a process that is
facilitated by immune checkpoint molecules such as programmed cell death protein 1 (PD1) …
facilitated by immune checkpoint molecules such as programmed cell death protein 1 (PD1) …
Physical biology of the cancer cell glycocalyx
The glycocalyx coating the outside of most cells is a polymer meshwork comprising proteins
and complex sugar chains called glycans. From a physical perspective, the glycocalyx has …
and complex sugar chains called glycans. From a physical perspective, the glycocalyx has …
Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting
R Pothuraju, S Rachagani, WM Junker… - Journal of Experimental …, 2018 - Springer
Background Pancreatic cancer (PC) is among foremost causes of cancer related deaths
worldwide due to generic symptoms, lack of effective screening strategies and resistance to …
worldwide due to generic symptoms, lack of effective screening strategies and resistance to …
[HTML][HTML] Glycosylation of cancer stem cells: function in stemness, tumorigenesis, and metastasis
Aberrant glycosylation plays a critical role in tumor aggressiveness, progression, and
metastasis. Emerging evidence associates cancer initiation and metastasis to the …
metastasis. Emerging evidence associates cancer initiation and metastasis to the …
Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated …
N Jonckheere, I Van Seuningen - Journal of translational medicine, 2018 - Springer
Background MUC4 is a membrane-bound mucin that promotes carcinogenetic progression
and is often proposed as a promising biomarker for various carcinomas. In this manuscript …
and is often proposed as a promising biomarker for various carcinomas. In this manuscript …
Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells
Background Glycosylation plays a critical role in the aggressiveness of pancreatic cancer
(PC). Emerging evidences indicate significant involvement of cancer stem cells (CSCs) in …
(PC). Emerging evidences indicate significant involvement of cancer stem cells (CSCs) in …
Engineered nucleic acids and methods of use thereof
S Bancel, JP Schrum, A Aristarkhov - US Patent 10,022,425, 2018 - Google Patents
DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical class O [C@@ H] 1 [C@
H](O)[C@@ H](CO) O [C@ H] 1N1C (= O) NC (= O) C= C1 DRTQHJPVMGBUCF …
H](O)[C@@ H](CO) O [C@ H] 1N1C (= O) NC (= O) C= C1 DRTQHJPVMGBUCF …
Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway
ST Chen, TC Kuo, YY Liao, MC Lin, YW Tien… - Oncogene, 2018 - nature.com
Mucins are heavily glycosylated proteins that play critical roles in the pathogenesis of
tumour malignancies. Pancreatic ductal adenocarcinoma (PDAC) is characterised by the …
tumour malignancies. Pancreatic ductal adenocarcinoma (PDAC) is characterised by the …
Ramifications of secreted mucin MUC5AC in malignant journey: a holistic view
Heavily glycosylated secreted mucin MUC5AC, by the virtue of its cysteine-rich repeats, can
form inter-and intramolecular disulfide linkages resulting in complex polymers, which in turn …
form inter-and intramolecular disulfide linkages resulting in complex polymers, which in turn …