Agnostic metagenomic next-generation sequencing (mNGS) has emerged as a promising
single, universal pathogen detection method for infectious disease diagnostics. This …

The emergence of novel zoonotic pathogens is one of the greatest challenges to global
health security. The advent of increasingly sophisticated diagnostics tools has revolutionized …

Outbreaks of novel and deadly viruses highlight global vulnerability to emerging diseases,
with many having massive health and economic impacts. Our adaptive toolkit—based …

Identifying the animal origins of RNA viruses requires years of field and laboratory studies
that stall responses to emerging infectious diseases. Using large genomic and ecological …

Metagenomic shotgun sequencing has the potential to transform how serious infections are
diagnosed by offering universal, culture-free pathogen detection. This may be especially …

Background The recent global emergence and re-emergence of arboviruses has caused
significant human disease. Common vectors, symptoms and geographical distribution make …

Background Viruses are key players regulating microbial ecosystems. Exploration of viral
assemblages is now possible thanks to the development of metagenomics, the most …

Species within the Neoromicia bat genus are abundant and widely distributed in Africa. It is
common for these insectivorous bats to roost in anthropogenic structures in urban regions …

Metagenomic shotgun sequencing (MSS) is a revolutionary approach to viral diagnostic
testing that allows simultaneous detection of a broad range of viruses, detailed taxonomic …

While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only
Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds …