Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the …

P Lewczuk, P Riederer, SE O'bryant… - The world journal of …, 2018 - Taylor & Francis
In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

[HTML][HTML] Gut microbiota dysfunction as reliable non-invasive early diagnostic biomarkers in the pathophysiology of Parkinson's disease: a critical review

AT Nair, V Ramachandran, NM Joghee… - Journal of …, 2018 - ncbi.nlm.nih.gov
Recent investigations suggest that gut microbiota affects the brain activity through the
microbiota-gut-brain axis under both physiological and pathological disease conditions like …

Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results

RER Slot, SCJ Verfaillie, JM Overbeek… - Alzheimer's research & …, 2018 - Springer
Background We aimed to describe the Subjective Cognitive Impairment Cohort (SCIENCe)
study design, to cross-sectionally describe participant characteristics, and to evaluate the …

The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: a review

O Hansson, A Mikulskis, AM Fagan, C Teunissen… - Alzheimer's & …, 2018 - Elsevier
Introduction Cerebrospinal fluid (CSF) biomarkers have the potential to improve the
diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical …

Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer's disease dementia in mild cognitive …

I Baldeiras, I Santana, MJ Leitão, H Gens… - Alzheimer's research & …, 2018 - Springer
Background Cerebrospinal fluid (CSF) biomarkers have been used to increase the evidence
of underlying Alzheimer's disease (AD) pathology in mild cognitive impairment (MCI) …

Relevance of Aβ42/40 Ratio for Detection of Alzheimer Disease Pathology in Clinical Routine: The PLMR Scale

S Lehmann, C Delaby, G Boursier… - Frontiers in aging …, 2018 - frontiersin.org
Background: Cerebrospinal fluid (CSF) biomarkers (Aβ peptides and tau proteins) improved
the diagnosis of Alzheimer's disease (AD) in research and clinical settings. We previously …

Clinical value of neurofilament and phospho-tau/tau ratio in the frontotemporal dementia spectrum

LHH Meeter, EG Vijverberg, M Del Campo… - Neurology, 2018 - AAN Enterprises
Objective To examine the clinical value of neurofilament light chain (NfL) and the phospho-
tau/total tau ratio (p/t-tau) across the entire frontotemporal dementia (FTD) spectrum in a …

Proteomic approaches for the discovery of biofluid biomarkers of neurodegenerative dementias

BC Carlyle, BA Trombetta, SE Arnold - Proteomes, 2018 - mdpi.com
Neurodegenerative dementias are highly complex disorders driven by vicious cycles of
intersecting pathophysiologies. While most can be definitively diagnosed by the presence of …

The EMIF-AD PreclinAD study: study design and baseline cohort overview

E Konijnenberg, SF Carter, M Ten Kate… - Alzheimer's research & …, 2018 - Springer
Background Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and
can precede clinical dementia by decades. So far it remains unclear how amyloid pathology …

Diagnostic value of cerebrospinal fluid tau, neurofilament, and progranulin in definite frontotemporal lobar degeneration

J Goossens, M Bjerke, S Van Mossevelde… - Alzheimer's research & …, 2018 - Springer
Background We explored the diagnostic performance of cerebrospinal fluid (CSF)
biomarkers in allowing differentiation between frontotemporal lobar degeneration (FTLD) …