PTEN/PTENP1:'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy
N Haddadi, Y Lin, G Travis, AM Simpson, NT Nassif… - Molecular cancer, 2018 - Springer
Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …
PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis
W Xu, Z Yang, C Xie, Y Zhu, X Shu, Z Zhang… - Journal of Experimental …, 2018 - Springer
Background Phosphatase and tensin homolog (PTEN) is an important tumor suppressor
gene, and its encoded protein has activities of both a protein phosphatase and a lipid …
gene, and its encoded protein has activities of both a protein phosphatase and a lipid …
Targeting the PI3K signalling as a therapeutic strategy in colorectal cancer
MS Fernandes, JM Sanches, R Seruca - Targeted Therapy of Colorectal …, 2018 - Springer
Colorectal cancer (CRC) remains one of the leading causes of cancer mortality worldwide.
Regarded as a heterogeneous disease, a number of biomarkers have been proposed to …
Regarded as a heterogeneous disease, a number of biomarkers have been proposed to …
EGFR and FGFR in Growth and Metastasis of Colorectal Cancer
Colorectal cancer (CRC) is the most important cause of tumor-related fatalities around the
world, and its distant metastasis is responsible for 40% of mortalities in the USA as well as …
world, and its distant metastasis is responsible for 40% of mortalities in the USA as well as …