Augmenting vaccine immunogenicity through the use of natural human anti-rhamnose antibodies
Utilizing natural antibodies to augment vaccine immunogenicity is a promising approach
toward cancer immunotherapy. Anti-rhamnose (anti-Rha) antibodies are some of the most …
toward cancer immunotherapy. Anti-rhamnose (anti-Rha) antibodies are some of the most …
A restricted role for FcγR in the regulation of adaptive immunity
MF Fransen, H Benonisson, WW van Maren… - The Journal of …, 2018 - journals.aai.org
By their interaction with IgG immune complexes, FcγR and complement link innate and
adaptive immunity, showing functional redundancy. In complement-deficient mice, IgG …
adaptive immunity, showing functional redundancy. In complement-deficient mice, IgG …
Formation of immune complexes with a tetanus-derived B cell epitope boosts human T cell responses to covalently linked peptides in an ex vivo blood loop system
EAK Fletcher, W van Maren, R Cordfunke… - The Journal of …, 2018 - journals.aai.org
Enhancing T cell responses against both viral and tumor Ags requires efficient costimulation
and directed delivery of peptide Ags into APCs. Long peptide vaccines are considered …
and directed delivery of peptide Ags into APCs. Long peptide vaccines are considered …
Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses
SM Mangsbo, EAK Fletcher, WWC van Maren… - Molecular …, 2018 - Elsevier
Immune complexes are potent mediators of cellular immunity and have been extensively
studied for their disease mediating properties in humans and for their role in anti-cancer …
studied for their disease mediating properties in humans and for their role in anti-cancer …
Sustained cross‐presentation capacity of murine splenic dendritic cell subsets in vivo
NI Ho, MGM Camps, EFE de Haas… - European journal of …, 2018 - Wiley Online Library
An exclusive feature of dendritic cells (DCs) is their ability to cross‐present exogenous
antigens in MHC class I molecules. We analyzed the fate of protein antigen in antigen …
antigens in MHC class I molecules. We analyzed the fate of protein antigen in antigen …
A simple method for measuring immune complex-mediated, Fc gamma receptor dependent antigen-specific activation of primary human T cells
Immune complex (IC) deposition of IgG containing autologous antigens has been observed
in autoimmunity. This can lead to IC-mediated antigen uptake and presentation by antigen …
in autoimmunity. This can lead to IC-mediated antigen uptake and presentation by antigen …
Molecular Pharming: Plant‐Made Vaccines
Research on the use of plants for the production of vaccine antigens has increased greatly
since the seminal studies published in the early 1990s. The initial strategy focused on oral …
since the seminal studies published in the early 1990s. The initial strategy focused on oral …
[PDF][PDF] A dual-color bioluminescence reporter mouse for simultaneous in vivo imaging of T cell localization and activation
JW Kleinovink, L Mezzanotte, G Zambito, M Fransen… - scholarlypublications …
Non-invasive imaging technologies to visualize the location and functionality of T cells are of
great value in immunology. Here, we describe the design and generation of a transgenic …
great value in immunology. Here, we describe the design and generation of a transgenic …
[图书][B] Ly6C+ Monocyte Acquisition, Cross-presentation and Cross-Priming of Cell-associated Antigen
SR Larson - 2018 - search.proquest.com
Recently it was shown that circulating murine Ly6C+ monocytes can traffic from the blood to
tissues and/or draining lymph nodes (LNs) after ingesting soluble antigens, and then cross …
tissues and/or draining lymph nodes (LNs) after ingesting soluble antigens, and then cross …