Pharmacokinetics–pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients
RP Veiga, JA Paiva - Critical Care, 2018 - Springer
Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …
management of critically ill patients and beta-lactams are the most common antibiotic class …
Development of a dosing nomogram for continuous-infusion meropenem in critically ill patients based on a validated population pharmacokinetic model
IK Minichmayr, JA Roberts, OR Frey… - Journal of …, 2018 - academic.oup.com
Background Optimal antibiotic exposure is a vital but challenging prerequisite for achieving
clinical success in ICU patients. Objectives To develop and externally validate a population …
clinical success in ICU patients. Objectives To develop and externally validate a population …
Effect of renal clearance and continuous renal replacement therapy on appropriateness of recommended meropenem dosing regimens in critically ill patients with …
R Burger, M Guidi, V Calpini, F Lamoth… - Journal of …, 2018 - academic.oup.com
Background Meropenem plasma concentration above a pathogen's MIC over the whole
dosing interval (100% ƒ T> MIC) is a determinant of outcome in severe infections. Significant …
dosing interval (100% ƒ T> MIC) is a determinant of outcome in severe infections. Significant …
The exploration of population pharmacokinetic model for meropenem in augmented renal clearance and investigation of optimum setting of dose
T Tamatsukuri, M Ohbayashi, N Kohyama… - Journal of Infection and …, 2018 - Elsevier
In recent years, augmented renal clearance (ARC), in which renal function is excessively
enhanced, has been reported, and its influence on β-lactam antibiotics has been …
enhanced, has been reported, and its influence on β-lactam antibiotics has been …
In Vivo Efficacy of Plazomicin Alone or in Combination with Meropenem or Tigecycline against Enterobacteriaceae Isolates Exhibiting Various Resistance …
K Abdelraouf, A Kim, KM Krause… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
Plazomicin is a novel aminoglycoside with potent in vitro activity against multidrug-and
carbapenem-resistant Enterobacteriaceae. The objective of this study was to assess the …
carbapenem-resistant Enterobacteriaceae. The objective of this study was to assess the …
[PDF][PDF] Inpatient antibiotic resistance: Everyone's problem
DE Wiskirchen, U Wu, M Summa, A Perrin - J Fam Pract, 2018 - cdn.mdedge.com
A 68-year-old woman is admitted to the hospital from home with acute onset, unrelenting,
upper abdominal pain radiating to the back and nausea/vomiting. Her medical history …
upper abdominal pain radiating to the back and nausea/vomiting. Her medical history …
[PDF][PDF] Population pharmacokinetics of meropenem in Vietnamese adult patients
Meropenem is a broad-spectrum antimicrobial frequently used for serious infections.
Understanding the pharmacokinetics of meropenem is crucial in optimizing the dosage …
Understanding the pharmacokinetics of meropenem is crucial in optimizing the dosage …
[引用][C] Aus der Klinik und Poliklinik für Anästhesiologie (Direktor: Univ.-Prof. Dr. med. Klaus Hahnenkamp) der Universitätsmedizin der Ernst-Moritz-Arndt-Universität …
HML Fürstenberg