Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …

Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles
(NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid …

Tau, a microtubule-associated protein, is the main component of the intracellular filamentous
inclusions that are involved in neurodegenerative diseases known as tauopathies, including …

Tau immunotherapies have now advanced from proof-of-concept studies to Phase II clinical
trials. This review briefly outlines developments in the field and discusses how these …

Introduction The abnormal hyperphosphorylation of the microtubule-associated protein tau
plays a crucial role in neurodegeneration in Alzheimer's disease (AD) and other …

The mouse is one of the organisms most widely used as an animal model in biomedical
research, due to the particular ease with which it can be handled and reproduced in …

Aggregation of tau protein and spreading of tau aggregates are pivotal pathological
processes in a range of neurological disorders. Accumulating evidence suggests that …

Background: Unlike antibodies against amyloid-β, little is known about serum antibodies to
neuron-specific cytoskeletal proteins in patients with Alzheimer's disease (AD). Objective …

Tau-immumotherapy has shown promising results in tangle/tauopathy-tg animal models.
Here we immunized amyloid-mice (APPSwe/PSEN1dE9-tg, presenting amyloid-plaques, not …