The arginine/glycine-rich region termed the RGG domain is usually found in G-quadruplex
(G4)-binding proteins and is important in G4–protein interactions. Studies on the binding …

Quadruplexes are four-stranded DNA or RNA structures formed from tandem repeats of
guanine-rich sequences. They are present throughout the genome, namely at telomeres, in …

KRAS is often found mutated in lethal cancers and should be an important target for
anticancer drug development. However, no effective inhibitor has been reported so far …

A promising anticancer therapeutic strategy is the stabilization of telomeric G-quadruplexes
using G-quadruplex-binding small molecules. Although many G-quadruplex-specific ligands …

Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which
display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA …

An improved microwave-induced synthesis of five ethidium derivatives (Ethidium derivatives,
2a–d) is presented. As the derivatives 2a–d have been proposed previously to be …

G-quadruplex, a unique secondary structure in nucleic acids found throughout human
genome elicited widespread interest in the field of therapeutic research. Being present in …

Résumé Le développement des nanoparticules fluorescentes, appelées quantum dots
(QDs) est devenu l'un des domaines les plus prometteurs de la science des matériaux …

G-Quadruplexe (G4) sind alternative Sekundärstrukturen, die von Guanosin-reichen DNA-
oder RNA-Sequenzen ausgebildet werden können. In den letzten Jahren rückten diese …

The primary focus and target of DNA-binding small molecules and therapeutic agents has
traditionally been double-helical DNA, ie the overwhelming component of the human and …